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目的研究低流量七氟醚吸入麻醉对新生儿肾功能的影响。方法 90例新生儿手术患儿,随机分为研究组和对照组,各45例。研究组患儿使用低流量七氟醚吸入麻醉,对照组患儿使用七氟醚吸入麻醉,观察比较两组患儿在各个时间段(手术前1 d、术后1 h、术后1 d、术后3 d)的肌酐、血清尿素氮含量变化情况。结果研究组手术后1 h肌酐为(54.66±4.39)mmol/L、手术后1 d肌酐为(54.71±4.45)mmol/L,手术后1 h血清尿素氮为(4.23±0.63)mmol/L,手术后1 d血清尿素氮(4.21±0.65)mmol/L,各个时间段的肌酐、血清尿素氮含量比较,差异无统计学意义,(P>0.05)。对照组中手术后1 h和1 d的肌酐、血清尿素氮含量均明显较高,接近于正常范围中上限水平,与本组手术前1 d和手术后3 d的含量比较,差异有统计学意义(P<0.05)。两组患者手术前1 d和手术后3 d的患儿肌酐、血清尿素氮含量比较,差异无统计学意义(P>0.05)。结论对新生儿实施低流量七氟醚吸入麻醉,不会对肾功能造成损害影响,其麻醉效果安全、有效,值得大力推广使用。
Objective To study the effects of low-dose sevoflurane inhalation anesthesia on neonatal renal function. Methods 90 cases of neonatal surgery were randomly divided into study group and control group, 45 cases in each group. The study group was treated with low-flow sevoflurane inhalation anesthesia, and the control group was anesthetized with sevoflurane inhalation anesthesia. At each time point (1 d before operation, 1 h after operation, 1 d after operation, 3 days after operation) creatinine, serum urea nitrogen content changes. Results The level of creatinine was (54.66 ± 4.39) mmol / L at 1 h after operation in the study group and (54.71 ± 4.45) mmol / L at 1 d after operation. Serum urea nitrogen was (4.23 ± 0.63) mmol / Serum urea nitrogen (4.21 ± 0.65) mmol / L at 1 d after operation showed no significant difference in creatinine and serum urea nitrogen in all time points (P> 0.05). The levels of creatinine and serum urea nitrogen in the control group were significantly higher at 1 h and 1 d after operation, close to the upper limit of normal range, compared with the 1 d before surgery and 3 d after surgery, the difference was statistically significant Significance (P <0.05). There was no significant difference in creatinine and serum urea nitrogen between the two groups before operation and 3 days after operation (P> 0.05). Conclusions The newborns with low-flow sevoflurane inhalation anesthesia will not cause any damage to renal function. The anesthetic effect is safe and effective, and it is worth promoting.