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目的:了解免疫因素在女性不孕中占的比率,以及流产和妇科炎症与免疫性不孕的关系。方法:用免疫金标记法检测患者血清中抗精子抗体(AsAb),抗子宫内膜抗体(EMAb)。抗绒毛膜促性腺激素抗体(hCGAb)(用ELISA法检测)。结果由于免疫因素导致的不孕占45.00%,其中以hCGAb阳性检出率最高41.34%;有流产史者AsAb、EMAb和hCGAb三种抗体阳性检出率均高于无流产史者,差异有显著性(P均<0.05);有妇科炎症者AsAb和EMAb阳性检出率均高于无炎症者,差异有显著性(P均<0.05);有流产史且伴有妇科炎症者三种抗体均高于单纯妇科炎症或者单纯流产者,且以EMAb阳性程度最显著,差异有显著性(P<0.05)。结论:流产和妇科炎症是导致女性免疫性不孕的重要原因。
Objectives: To understand the proportion of immune factors in female infertility and the relationship between abortion and gynecological inflammation and immune infertility. Methods: Serum anti-sperm antibody (AsAb) and anti-endometrial antibody (EMAb) were detected by immunogold labeling. Anti-chorionic gonadotropin antibody (hCGAb) (detected by ELISA). Results As a result of immune factors accounted for 45.00% of infertility, of which hCGAb positive detection rate was the highest 41.34%; with abortion history AsAb, EMAb and hCGAb three antibody positive detection rate were higher than those without abortion history, the difference was significant (P <0.05). The positive rates of AsAb and EMAb in gynecological inflammation were higher than those without inflammation (all P <0.05). All three antibodies with history of miscarriage and gynecological inflammation Higher than simple gynecological inflammation or simple abortion, and the most significant positive EMAb, the difference was significant (P <0.05). Conclusion: Abortion and gynecological inflammation are the important causes of female infertility.