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地霉素的临床应用逐漸增加,但靜脈注射能引起皮肤坏死,尚为人們所忽略。我院外科于1964年4月至八月,曾因靜脈注射地霉素(上海新亚药厂制)发生皮肤坏死两例,报告如下: 例一:男嬰,一个月,住院号3224。因发冷发烧两天,左颌下肿胀三天,临床診断为左颌下蜂窝織炎,敗血症,于1964年6月18日住院。入院后曾給予青霉素、鏈霉素肌肉注射,并用盐酸地霉素0.5克溶于5％葡萄糖溶液500毫升(每毫升含地霉素1.0毫克)內靜脈滴注。因患兒肥胖,病势险恶,多次靜脈穿刺失敗后,改用右大腿內側皮下滴注。于滴后24小时,发现該区皮肤坏死,境界清楚,直径3×2厘米,48小时左右形成溃
Clinical application of gemcitin gradually increased, but intravenous injection can cause skin necrosis, but still ignored by people. Surgery in our hospital from April 1964 to August, once due to intravenous gemcitabine (Shanghai New Asia Pharmaceutical Factory) occurred in two cases of skin necrosis, the report is as follows: Example 1: a baby boy, one month, hospital number 3224. Fever due to chills for two days, swelling of the left mandibular three days, clinical diagnosis of left submandibular cellulitis, sepsis, hospitalized on June 18, 1964. Penicillin and streptomycin were injected intramuscularly after hospital admission and intravenously infused with 0.5 g of gemcitabine hydrochloride in 500 ml of 5% dextrose solution (1.0 mg per ml with gemcitabine). Due to children with obesity, the risk of evil, repeated venipuncture failure, the switch to the right thigh medial subcutaneous drip. 24 hours after dripping, found that the area of skin necrosis, the realm of clear, diameter 3 × 2 cm, about 48 hours to form ulceration