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目的 比较冠通I号与血脂平对高脂血症的疗效。方法 将 15 0例原发性高脂血症患者随机分为两组 ,每组 75人 :第一组口服冠通I号胶囊 ,15g/次 ,3次 /日 ;第二组口服血脂平 ,0 .6g/次 ,3次 /日 .1两组治疗前后 ,分别查血脂 (TC ,TG ,LDL -C ,HDL -CApoAApoB10 0 ) ,并计算动脉粥样硬化指数 (AI)。结果 两组治疗前后自身比较TC ,TG ,LDL -C ,AI及ApoB10 0均明显下降 ,HDL -C明显上升 ,差”异有非常显著性意义 (P <0 .0 1)。两组组间比较差别无显著性意义 (P >0 .0 5 )。结论 冠通I号能有效地降低原发性高血脂患者的血脂 ,其疗效及安全性与血脂平相近。而且冠通I号属纯中药制剂 ,不良反应轻 ,价格低廉 ,具有较好的临床应用前景。
Objective To compare the efficacy of Guan Tong I and Xuezhiping on hyperlipidemia. Methods Fifty patients with primary hyperlipidemia were randomly divided into two groups with 75 patients in each group: the first group was orally administered with Guan-guan I capsules at 15g / time for 3 times daily; the second group was orally administered with lipid- 0 .6g / time, 3 times / day .1 Before and after treatment, blood lipid (TC, TG, LDL-C, HDL-CApoAApoB10 0) and the atherosclerosis index (AI) were calculated. Results The levels of TC, TG, LDL-C, AI and ApoB10 0 in the two groups before and after treatment were significantly decreased, and HDL-C significantly increased, with significant difference (P <0.01) The difference was not significant (P0.05) .Conclusion Guantong I can effectively reduce the blood lipid in patients with primary hyperlipidemia, its efficacy and safety and blood lipid level similar to and Guan Tong No. I is pure Chinese medicine preparations, adverse reactions, low prices, has good clinical application prospects.