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目的探讨乳腺癌患者淋巴管内透明质酸Layilin受体表达情况及临床意义。方法自2016年1-12月,连续性收集赣南医学院第一附属医院收治的乳腺癌患者98例,同期收集50例乳腺纤维瘤患者,检测不同组织中Layilin受体表达情况并计算淋巴管密度,分析Layilin受体标记的淋巴管密度与乳腺癌患者临床特征的相关性。结果与纤维瘤组织比较,乳腺癌组织中透明质酸Layilin受体阳性淋巴管密度显著增高(P=0.000)。与无淋巴结转移的患者相比,淋巴结转移的患者淋巴管密度显著增高(P=0.001);与TNM分期为Ⅰ或Ⅱ期的患者相比,TNM分期为Ⅲ或Ⅳ期的患者淋巴管密度显著增高(P=0.000)。结论乳腺癌患者淋巴管内透明质酸Layilin受体高表达可能与肿瘤细胞的转移有关。
Objective To investigate the expression of Layilin receptor in lymphatic vessels in patients with breast cancer and its clinical significance. Methods From January to December in 2016, 98 cases of breast cancer were collected from the First Affiliated Hospital of Gannan Medical College. 50 cases of breast fibroids were collected in the same period. The expression of Layilin receptor in different tissues was detected and lymphatic Density, analysis of Layilin receptor labeled lymphatic vessel density and clinical features of patients with breast cancer. Results Compared with fibroid tissue, the density of Layilin receptor-positive lymphatic vessels in breast cancer tissues was significantly increased (P = 0.000). Compared with patients without lymph node metastasis, lymph node density was significantly increased in patients with lymph node metastasis (P = 0.001). Compared with patients with TNM stage Ⅰ or Ⅱ, lymphatic vessel density was significantly higher in patients with TNM stage Ⅲ or Ⅳ Increased (P = 0.000). Conclusion The high expression of Layilin receptor in lymphatic vessels of breast cancer patients may be related to the metastasis of tumor cells.