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目的了解甘肃省2010年不同时期一般人群甲型H1N1流感(甲流)抗体水平变化及季节性流感抗体水平。方法采用血凝抑制(Hemagglutination Inhibition,HI)试验检测HI抗体,≥1:40为阳性。结果2009年8月、12月、2010年1月、2月、3月及9月底甘肃省城市人群甲流抗体阳性率分别为3.64%(11/302)、10.45%(44/421)、17.30%(55/318)、20.29%(70/345)、33.69%(94/279)和27.75%(111/400),9月份季节性流感H1N1、H3N2、B(Victorian)和B(yamagata)毒株抗体阳性率分别为30.25%(121/400)、15.50%(62/400)、12.75%(51/400)和5.00%(20/400)。结论甘肃省甲流首先在学生中出现,甲流HI抗体水平从流行初期的3.64%逐步上升至流行结束的33.69%;2010年9月人群中甲流及季节性H1N1流感病毒抗体阳性率相对较高,H3N2及B(yamagata)系病毒抗体阳性率较低。建议加强流感疫苗的接种,做好学校等集体单位流感样暴发疫情的防控工作。
Objective To understand the level of antibody against influenza A (H1N1) and the level of seasonal influenza antibody in the general population in Gansu Province at different periods in 2010. Methods HI antibody was detected by Hemagglutination Inhibition (HI) test, and ≥1: 40 was positive. Results The positive rates of influenza A antibody in urban population of Gansu Province in August, December, 2010, January, February, March and September 2010 were 3.64% (11/302), 10.45% (44/421) and 17.30 (55/318), 20.29% (70/345), 33.69% (94/279) and 27.75% (111/400) respectively. The seasonal influenza H1N1, H3N2, B (Victorian) and B (yamagata) The positive rates of monoclonal antibodies were 30.25% (121/400), 15.50% (62/400), 12.75% (51/400) and 5.00% (20/400), respectively. Conclusion The first A-like H1N1 antibody in Gansu Province appeared among the students. The HI antibody level of A-H1N1 increased gradually from 3.64% at the initial stage to 33.69% at the end of the epidemic. In September 2010, the prevalence of H1N1 influenza A virus in the crowd was relatively high High, H3N2 and B (yamagata) virus-positive rate is low. Propose to strengthen the vaccination of the flu and do a good job in prevention and control of flu-like outbreaks among the collective units such as schools.