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目的探讨女性静脉注射吸毒(IDUs)感染艾滋病病毒(HIV)的危险因素,为制定针对这一人群的干预措施提供理论依据。方法通过1∶1配对50对女性IDUs病例对照研究,探索其感染HIV的危险因素。结果对各个变量进行单因素条件Logistic回归分析后发现,与HIV感染有显著相关的因素有:无固定居所、共用针具史、过去1年有多性伴或以性换钱/毒品、有HIV阳性固定性伴、有IDU性伴、有暴力虐待史、曾感染梅毒、认为自己有很大/一定感染HIV危险。HIV感染的危险因素为:有HIV阳性的固定性伴(OR=28.05;95%CI=2.34,335.67),过去一年曾以性换钱/毒品(OR=5.89;95%CI=1.12,31.09),以及无固定居所(OR=10.77;95%CI=1.21,96.06)。结论广东省的女性IDUs中,性行为较注射行为对于HIV传播更为危险,干预重点应该放在如何减少在吸毒情况下经性途径传播HIV的危险因素上。
Objective To investigate the risk factors of HIV infection in female intravenous drug abuse (IDUs) and provide a theoretical basis for the development of interventions targeting this population. Methods A matched case-control study of 50 female IDUs with 1: 1 pairing was performed to explore the risk factors for HIV infection. Results After univariate conditional logistic regression analysis of each variable, it was found that there were significant correlations with HIV infection among the following: no permanent residence, history of needle sharing, multiple sexual partners in the past year or sexual exchange for money / drug, HIV positive Persistent sexual partners, partners with IDU, history of violent mistreatment, syphilis infection, think they have a great / certain risk of HIV infection. The risk factors for HIV infection were HIV-positive immobility partners (OR = 28.05; 95% CI = 2.34, 335.67) and sex / money exchange during the past year (OR = 5.89; 95% CI = 1.12, 31.09) , And no permanent residence (OR = 10.77; 95% CI = 1.21, 96.06). Conclusions Sexual behaviors among female IDUs in Guangdong Province are more dangerous for HIV transmission than those for injections. The focus of intervention should be on reducing the risk factors for HIV transmission sexually through drug use.