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目的:探讨表达性书写在中青年结直肠癌患者中的应用效果，为临床干预提供依据。方法:采用便利抽样法，选取2019年1—11月于广西医科大学第一附属医院行手术治疗的中青年结直肠癌患者92例为研究对象。采用随机方法将其分为对照组（n n=48）和观察组（n n=44）。对照组患者实施结直肠癌患者住院期间常规护理，观察组患者在常规护理的基础上增加表达性书写干预。分别于患者入院后1~2 d及出院前1 d完成简式简明心境问卷、人生意义问卷、匹兹堡睡眠质量指数的测评。n 结果:最终对照组回收有效问卷44份，观察组回收有效问卷43份。干预后，两组患者简式简明心境问卷中紧张-焦虑、抑郁-沮丧、疲乏-迟钝、迷惑-混乱、精力-活力维度得分比较，差异均有统计学意义（n P<0.05）。干预后观察组患者人生意义问卷中的存在生命意义感和寻找生命意义感维度得分均高于对照组，差异有统计学意义（n P0.05）。n 结论:表达性书写对中青年结直肠癌患者改善负性情绪和人生意义感有积极作用。“,”Objective:To explore the effect of expressive writing in young and middle-aged patients with colorectal cancer, so as to provide a basis for clinical intervention.Methods:From January to November 2019, convenience sampling was used to select 92 young and middle-aged colorectal cancer patients who underwent surgery in the First Affiliated Hospital of Guangxi Medical University as the research objects. Patients were divided into control group (n n=48) and observation group (n n=44) by the random method. Patients in control group received routine care during hospitalization for patients with colorectal cancer, and patients in observation group added expressive writing intervention on the basis of routine care. The Profile of Mood State-Short Form (POMS-SF) , Meaning in Life Questionnaire (MLQ) , Pittsburgh Sleep Quality Index (PSQI) were used to evaluation one to two days after admission and one day before discharge.n Results:A total of 44 valid questionnaires were returned in control group and 43 valid questionnaires in observation group. After intervention, there were statistical differences in the dimension scores of tension-anxiety, depression-frustration, fatigue-indulgence, confusion-mull and energy-vigor in POMS-SF of patients between two groups (n P<0.05) . After intervention, the scores of the sense of meaning of life and searching for the meaning of life in the MLQ of observation group were higher than those of control group, and the differencs were statistically significant (n P0.05) .n Conclusions:Expressive writing has a positive effect on improving negative emotions and sense of meaning in life for young and middle-aged patients with colorectal cancer.