论文部分内容阅读
目的分析海南省疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)发生特征,评价AEFI信息管理系统运转质量和疫苗安全性,指导预防接种工作。方法通过全国AEFI信息管理系统收集海南省2011-2013年AEFI监测数据,采用描述流行病学方法进行分析。结果海南省2011-2013年共报告AEFI 3 860例,报告发生率为3.14/万剂。AEFI报告市县覆盖率100.00%,48 h及时报告率96.35%,48 h及时调查率99.44%。AEFI分类一般反应占73.91%,异常反应占21.99%,偶合症3.89%,其他反应占0.21%,异常反应主要以过敏性皮疹、卡介苗淋巴结炎和血管性水肿为主。全年均有AEFI报告,5月和11月报告AEFI最多,男女性别比例为1.60∶1,3岁内儿童报告最多。AEFI转归情况:治愈占99.80%,后遗症4例,死亡4例。结论海南省AEFI监测敏感性较高;AEFI主要以一过性反应为主,目前所使用的疫苗是安全的;需加强对基层接种人员接种技术培训。
Objective To analyze the characteristics of AEFI in Hainan Province and evaluate the operational quality and vaccine safety of AEFI information management system to guide vaccination. Methods The national AEFI information management system was used to collect the AEFI data from 2011-2013 in Hainan Province, and the descriptive epidemiological method was used to analyze the data. Results A total of 860 cases of AEFI were reported in Hainan Province from 2011 to 2013, with a reported incidence of 3.14 / dose. AEFI report city coverage 100.00%, 48 h timely reporting rate of 96.35%, 48 h timely investigation rate of 99.44%. AEFI classification of the general reaction accounted for 73.91%, abnormal response accounted for 21.99%, coupling 3.89%, other reactions accounted for 0.21%, the main anaphylactic reaction allergic rash, BCG and angioedema mainly. The AEFI report is available all year round, with the highest AEFI reported in May and November, with a male / female ratio of 1.60: 1. AEFI to the situation: the cure accounted for 99.80%, 4 cases of sequelae, 4 cases of death. Conclusion The sensitivity of AEFI monitoring in Hainan Province is high. AEFI is mainly based on a transient reaction. The vaccines currently used are safe and the vaccination training for grass-roots vaccinators should be strengthened.