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目的:调查、分析、总结我院临床用药中产生的药品不良反应(ADR)情况,分析药源性损害发生的相关因素。方法:整理汇总本院2007年1月～2008年4月的不良反应报告142例进行了回顾性调查、统计、分析,内容包括:病人性别、年龄、分类(住院或门诊)、药物名称、剂型、用法、不良反应类型、主要临床表现、报告人职业、因果关系和转归情况。结果与结论:ADR的构成比基本随着年龄的增加而增加,老年患者的ADR构成比较大,女性多于男性;抗感染药物引起的不良反应例数最多(45.96%),其次是中成药(26.71%);左氧氟沙星注射液排列第一(9.93%),其次是血栓通注射液(6.21%);注射剂的不良反应占首位(65.22%);静脉滴注不良反应构成比最高(60.25%);ADR所涉及的器官系统以皮肤及其附件最常见;其次是全身性损害;所有ADR的患者中,单一用药110例(77.46%),联合用药32例(22.54%)。不良反应报告还存在着上报率较低、质量不高等现象。ADR监测工作任重道远。
OBJECTIVE: To investigate, analyze and summarize the adverse drug reactions (ADRs) in clinical medicine in our hospital and analyze the related factors of drug induced damage. Methods: A total of 142 cases of adverse reactions reported in our hospital from January 2007 to April 2008 were retrospectively surveyed, statistically analyzed and analyzed. The contents include: patient’s sex, age, classification (hospital or outpatient), drug name, dosage form , Usage, types of adverse reactions, major clinical manifestations, occupational reporting, causal relationships and outcome. RESULTS AND CONCLUSION: The ADR constitutional ratio increased with age. The incidence of ADR in elderly patients was larger than that in males. The number of adverse reactions caused by anti-infective drugs was the highest (45.96%), followed by that of proprietary Chinese medicines 26.71%). Levofloxacin injection was the first (9.93%), followed by Xueshuantong injection (6.21%). The adverse reaction of injection was the highest (65.22%), the highest ratio of intravenous infusion of adverse reaction was 60.25% The organ systems involved in ADR were most common with skin and its appendages, followed by generalized lesions. Of all patients with ADR, 110 (77.46%) were given monotherapy and 32 (22.54%) received combination therapy. Adverse reactions to the report there is also a lower rate of return, the quality is not high and so on. ADR monitoring long way to go.