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临床研究证实炎症在动脉粥样硬化损伤的各阶段均有重要作用,包括从脂纹形成到最终易损斑块的破裂。炎症标记物可以反映与急性冠状动脉综合征的各个阶段相关联的动脉粥样硬化进程的不同侧面,还可能与急性冠状动脉综合征的严重性有关。该综述总结了有关炎症标记物的文献,为使用炎症标记物检测易损斑块的可行性提供了一些证据。这些证据可能会促使动脉粥样硬化患者的管理更加完善,包括一级预防和二级预防。
Clinical studies have confirmed that inflammation plays an important role in various stages of atherosclerotic lesions, including from the formation of lipid stripes to the rupture of the final vulnerable plaque. Inflammatory markers can reflect different aspects of the atherosclerotic process associated with each stage of acute coronary syndrome and may also be related to the severity of acute coronary syndrome. This review summarizes the literature on inflammatory markers and provides some evidence for the feasibility of using inflammatory markers to detect vulnerable plaque. This evidence may lead to better management of patients with atherosclerosis, including primary and secondary prevention.