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业已确定位于第6号染色体短臂上的人类白细胞抗原区(HAL)的几个其他基因与Graves病和Ⅰ型糖尿病(胰岛素依赖型,IDDM)的遗传易感性有关联。基因定位于男性Y—染色体2233的细胞毒性T淋巴细胞抗原4(CTLA_4)。作者研究了Graves病和IDDM的CTLA_4第一外显子多态性分布。这种多态性表现在蛋白质肽链端的17位氨基酸改变。采用聚合酶链反应(PCR)和多态性方法对305名Graves病人、293名IDDM病人以及325名对照者进行分析。结果发现Graves病组丙氨酸等位基因比
Several other genes that have been identified as Human Leukocyte Antigen (HAL) on the short arm of chromosome 6 have been linked to genetic susceptibility to Graves’ disease and Type 1 diabetes (insulin-dependent, IDDM). The gene is localized to cytotoxic T lymphocyte antigen 4 (CTLA_4) on male Y-chromosome 2233. The authors studied the CTLA_4 exon 1 polymorphism distribution in Graves disease and IDDM. This polymorphism is reflected in the 17 amino acid changes in the peptide chain terminus. 305 Graves patients, 293 IDDM patients and 325 controls were analyzed by polymerase chain reaction (PCR) and polymorphism. The results showed that the alanine allele ratio of Graves disease group