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酰氯是一类非常重要的有机合成中间体,在农药合成中有着广泛的应用,高效、低毒、低成本和对环境友好是新农药创制的基本要求。以酰氯为中间体,通过醇解或胺解,以及对取代基的修饰和活性结构的拼接(例如具高生物活性的吡啶杂环、苯并杂环、噁二嗪、氟原子等基因的引入)等方法能合成出许多结构新颖且具备高生物活性的农药。以氯乙酰氯为酰化剂,通过对噁二嗪类化合
Acid chlorides are a very important class of organic synthesis intermediates and have been widely used in the synthesis of pesticides. High efficiency, low toxicity, low cost and environmental friendliness are the basic requirements of new pesticide creation. With acyl chloride as an intermediate, by alcoholysis or amineysis, as well as modification of substituents and splicing of active structures (for example, the introduction of genes such as pyridine heterocycles with high biological activity, benzoheterocycles, oxadiazines, fluorine atoms and the like ) And other methods can be synthesized many new and highly bio-active pesticides. Chloroacetyl chloride as acylating agent, through the dioxazine compound