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该文追踪观察２５例用α－干扰素治疗后复制指标转阴的慢性乙型肝炎患者４年，至观察结束时，共有１８例患者复制指标转阳（７２％，１８／２５），其中１年内转阳者１３例（７２．２％，１３／１８）。感染时间在７年内转阳者为５５．５％（５／９），在７年以上转阳者为８１．２％（１３／１６），二者比较有显著性差异（Ｐ＜０．０５）。复发与使用干扰素类型无关，复发时均伴有ＡＬＴ增高。
The article tracked 25 patients with chronic hepatitis B who were negative for replication index after treatment with α-interferon for 4 years. By the end of observation, a total of 18 patients had positive conversion (72%, 18/25), of which 1 During the year, 13 cases were positive for Yang (72.2%, 13/18). The infection time was 55.5% (5/9) in 7 years and 81.2% (13/16) in 7 years or more, the difference was significant (P <0.05 ). Recurrence and use of interferon type has nothing to do, recurrence associated with ALT increased.