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自从 198 7年Ｐａｌｍｅｒ等首次证实内皮舒张因子 (ＥＤＲＦ)即一氧化氮 (ＮＯ)。作为一种重要的信使物质和神经递质 ,其生理和病理作用引起学者们广泛的重视。 90年代以来 ,人们日益重视ＮＯ与心肌舒缩功能的关系。许多研究表明ＮＯ可能通过参与心肌能量代谢而调节心脏的功能
Palmer et al. First confirmed EDFF (nitric oxide) since 1984. As an important messenger substance and neurotransmitter, its physiological and pathological effects arouse widespread attention of scholars. Since the 90s, people pay more attention to the relationship between NO and myocardial systolic and diastolic function. Numerous studies show that NO may regulate cardiac function by participating in myocardial energy metabolism