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目的了解甘肃省兰州市中老年人非酒精性脂肪性肝病(NAFLD)患病情况、特点、危险因素。方法整群抽取某社区40~75岁3 183名居民进行问卷调查,体格检查,检测血糖、血脂、肝酶等及上腹部超声检查。结果 NAFLD患病率为25.5%(标化率22.9%);女性27.0%高于男性的21.8%(P<0.01);女性及<60岁的男性中,NAFLD患病率随着年龄增加而逐渐升高(P<0.01);logistic回归分析显示,体质指数,甘油三酯,糖化血红蛋白,腰臀比是男女性NAFLD的共同的危险因素,腰围、空腹血糖、餐后2 h血糖是女性特有危险因素。结论兰州市中老年人约25%患有NAFLD,超重、甘油三酯及糖化血红蛋白升高及高腰臀比增加NAFLD患病风险。
Objective To understand the prevalence, characteristics and risk factors of non-alcoholic fatty liver disease (NAFLD) among middle-aged and elderly people in Lanzhou, Gansu Province. Methods A total of 3 183 residents aged 40-75 years in a community were selected for questionnaire survey, physical examination, blood sugar test, lipids, liver enzymes and upper abdominal ultrasound examination. Results The prevalence of NAFLD was 25.5% (normalized rate was 22.9%). Female 27.0% was higher than male 21.8% (P <0.01). In both women and men <60 years old, the prevalence of NAFLD gradually increased with age Logistic regression analysis showed that body mass index, triglyceride, glycosylated hemoglobin and waist-to-hip ratio were the common risk factors of NAFLD in men and women. Waist circumference, fasting blood glucose and postprandial blood glucose of 2 h were the risk of women factor. Conclusion About 25% of middle-aged and elderly people in Lanzhou suffer from NAFLD, overweight, elevated triglyceride and glycosylated hemoglobin, and high waist-hip ratio increase the risk of NAFLD.