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目的比较雷帕霉素(CYPHER)和紫杉醇(TAXUS)药物洗脱支架(DES)在冠心病复杂病变中的临床近、远期疗效。方法本研究选自2002年4月～2004年6月期间接受 CYPHER 和 TAXUS DES 治疗的患者各为611例和450例,两组的临床情况和入选的病变类型具有可比性。结果 CYPHER 和 TAXUS DES 置入成功率分别为99.2%和98.8%,住院期间心脏事件(死亡,AMI,靶病变重建,MACE)发生率各为0.65%和1.3%(P>0.05),6～8个月随访率各为97.5%和96.2%,随访期间 MACE 发生率分别为2.3%和3.2%(P>0.05),再狭窄发生率分别为7.3%和14%(P>0.05)。结论研究结果提示,对于冠心病复杂性病变 CYPHER 和 TAXUS DES 均有良好的临床近、远期疗效,在再狭窄发生率上 CYPHER 支架有优于 TAXUS支架的趋势。
Objective To compare the clinical short-term and long-term effects of CYPHER and TAXUS drug-eluting stents (DES) in complicated lesions of coronary heart disease. Methods Sixty-one and four hundred and fifty-five patients with CYPHER and TAXUS DES were enrolled in this study from April 2002 to June 2004. The clinical status of the two groups was comparable to the type of lesions selected. Results The success rates of CYPHER and TAXUS DES were 99.2% and 98.8%, respectively. The incidence of cardiac events (death, AMI, target lesion reconstruction and MACE) during hospitalization were 0.65% and 1.3% respectively (P> 0.05) The monthly follow-up rates were 97.5% and 96.2% respectively. The incidence of MACE during follow-up was 2.3% and 3.2% respectively (P> 0.05). The incidence of restenosis was 7.3% and 14% respectively (P> 0.05). Conclusions The results suggest that CYPHER and TAXUS DES have good clinical short-term and long-term curative effect on the complicated lesions of coronary heart disease. CYPHER stent is superior to TAXUS stent in the incidence of restenosis.