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目的通过经阴道彩色多普勒超声及免疫组化检测不明原因不孕患者子宫内膜及内膜下血流灌注及子宫内膜微血管密度(MVD),并与健康育龄妇女对比,以探讨子宫内膜及内膜下血流灌注与不明原因不孕的关系。方法在正常月经周期中的增殖晚期、排卵期与种植窗口期,通过经阴道彩色多普勒超声和免疫组化,检测不明原因不孕患者(n=16)与健康育龄妇女(n=13)的子宫内膜及内膜下血流灌注和子宫内膜MVD,分析子宫内膜及内膜下血流灌注与子宫内膜MVD在两组间的差异。结果在增殖晚期,健康育龄妇女的子宫内膜及内膜下血流灌注比不明原因不孕妇女丰富(P=0.026)。在增殖晚期与排卵期,健康育龄妇女的子宫内膜MVD高于不明原因妇女(P=0.001,P=0.027)。结论受损的子宫内膜及内膜下血流灌注可能是不明原因不孕的病因之一,经阴道彩色多普勒超声也许能成为诊断不明原因不孕的无创性手段之一。
Objective To detect the endometrial and subintimal blood flow perfusion and endometrial microvessel density (MVD) by vaginal color Doppler ultrasound and immunohistochemistry in patients with unexplained infertility and to compare with healthy women of childbearing age to explore the relationship between intrauterine Relationship between membrane and subintimal blood flow perfusion and unexplained infertility. Methods In the late stage of normal menstrual cycle, ovulation period and implantation window, vaginal color Doppler ultrasound and immunohistochemistry were used to detect unexplained infertility (n = 16) and healthy women of childbearing age (n = 13) Endometrial and subendothelial flow perfusion and endometrial MVD, and analyzed the differences between endometrial and submerged blood perfusion and endometrial MVD in both groups. Results In the late stage of proliferation, endometrial and subintimal blood flow in healthy women of childbearing age were more abundant than unexplained infertile women (P = 0.026). In late proliferative and ovulation stages, MVD in healthy women of childbearing age was higher than in women of unknown cause (P = 0.001, P = 0.027). Conclusion Impaired endometrial and subintimal blood flow perfusion may be one of the causes of unexplained infertility. Transvaginal color Doppler ultrasound may be one of the noninvasive means to diagnose unexplained infertility.