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目的 :观察部位麻醉时应用乙咪酯自控镇静 (PCS)对患者的作用.方法 :选择ASAⅠ~Ⅱ部位麻醉患者 2 0例.术中采用乙咪酯PCS.使用Graseby镇痛泵静脉给药 ,每次给药量为 1mg ,2 0秒完成 ,无锁定时间 ,患者可根据需要按压给药按扭 ,直至满意.每 5分钟记录一次镇静程度、呼吸通畅程度、SpO2 、BP、HR、患者按压的次数和实际给药次数.结果 :乙咪酯PCS起效时间为 2 1± 1 3分钟.在 2 4 0次记录中无一镇静过度.所有患者SpO2 及呼吸道通畅度均未受影响.在PCS初 5分钟按压次数和实际给药次数均较多 (P“,”Objective:ToObservetheeffectofpatient controlledsedation (PCS) providedbyinfusionofetomidate. Methods:Twentyregionalanesthesiapatients (ASAⅠ~Ⅱ )withPCSbyetomidate 1mgover 2 0swithoutlockoutwere studied .Patientscouldpressthebuttonasoftenasnecessary .Sedationlevel,BP ,HR ,SpO2 ,thenumberofdemandsfor sedationandthedosesactuallyinfusedwererecordedper 5min .Results :Theonsetofsedationwas 2 1± 1 3min .Nopa tientwasoversedated .SpO2 andairwayconditionweregoodinallpatients,andBP ,HRwerestable.Thenumberofde mandsandactuallyinfuseddosesduringthefirst 5minwerearound 7 1and 4 7respectively ,thendecreasedsignificantlyaf ter 10min (P <0 0 1) ,andkeptinlowerlevelduringthewholecourse.95 %ofpatientsweresatisfactorywithPCS .Con clusion :PCSwithetomidateissafe ,reliableduringregionalanesthesia .