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目的探讨脑梗死与颈动脉粥样斑块的相关性。方法选择2006年1月至2007年11月沈阳医学院沈洲医院神经内科220例脑梗死患者为脑梗死组,另选其他住院患者104例为对照组,两组患者的颈动脉采用血管外超声测定内膜中层厚度(IMT)及斑块形成,并检验血压、空腹血糖、总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白、纤维蛋白原、尿酸等。结果脑梗死组胆固醇、低密度脂蛋白、纤维蛋白原、颈动脉IMT、斑块检出率均较高,差异有统计学意义。两组在年龄、血压、血糖、尿酸,高密度脂蛋白、三酰甘油,差异无统计学意义。有斑块组与无斑块组比较,年龄低密度脂蛋白、尿酸差异有统计学意义。结论脑梗死的动脉斑块发生率高,颈动脉超声可作为检测动脉斑块的无创的敏感性指标,年龄、低密度脂蛋白,尿酸对斑块形成可能有一定意义。
Objective To investigate the correlation between cerebral infarction and carotid artery plaque. Methods From January 2006 to November 2007, 220 cerebral infarction patients in Shenzhou Hospital of Shenyang Medical College were enrolled in cerebral infarction group, and 104 other hospitalized patients were selected as control group. The carotid artery of the two groups were treated with extravascular ultrasound IMT and plaque formation were measured. Blood pressure, fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, fibrinogen and uric acid were measured. Results Cholesterol, low density lipoprotein, fibrinogen, carotid artery IMT and plaque detection rate in cerebral infarction group were higher, the difference was statistically significant. The two groups in age, blood pressure, blood glucose, uric acid, high density lipoprotein, triglyceride, the difference was not statistically significant. Compared with plaque group and no plaque group, the difference of age-low density lipoprotein and uric acid had statistical significance. Conclusions Cerebral infarction has a high incidence of arterial plaque. Carotid artery ultrasound can be used as a noninvasive and sensitive index for detecting arterial plaque. Age, low density lipoprotein and uric acid may have some significance for plaque formation.