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目的:研究黄龙疏喘汤联合孟鲁司特钠治疗支气管哮喘的疗效及对气道炎症及呼出NO的影响。方法:选取我院2012年2月至2014年2月支气管哮喘患者120例,随机抽签分为观察组与对照组各60例,观察组给予黄龙疏喘汤联合孟鲁司特钠治疗,对照组给予孟鲁司特钠治疗。观察两组临床疗效,比较两组治疗前后哮喘控制测试(ACT)评分、呼出NO水平,比较两组治疗前后炎性因子(IL-4、IL-25、IL-33)水平变化及肺功能改善情况。结果:观察组治疗总有效率(93.33%)显著高于对照组(78.33%)(P<0.05);观察组ACT评分显著高于对照组,呼出NO水平显著低于对照组(P<0.05);观察组炎性因子IL-4、IL-25、IL-33水平显著低于对照组(P<0.05);观察组FVC、FEV1、FEV1/FVC等肺功能指标显著高于对照组(P<0.05)。结论:黄龙疏喘汤联合孟鲁司特钠治疗支气管哮喘效果显著,患者炎性因子显著降低,肺功能得到有效改善。
Objective: To study the curative effect of Huanglongshu soup combined with montelukast on bronchial asthma and its effect on airway inflammation and exhaled NO. Methods: A total of 120 patients with bronchial asthma from February 2012 to February 2014 in our hospital were randomly divided into observation group (60 cases) and control group (60 cases). The observation group was treated with Huanglongshu soup combined with montelukast sodium, while the control group Give montelukast sodium treatment. The clinical curative effect of the two groups were observed. The ACT score and exhaled NO level were compared between the two groups before and after treatment. The levels of inflammatory cytokines (IL-4, IL-25, IL-33) Happening. Results: The total effective rate (93.33%) in the observation group was significantly higher than that in the control group (78.33%) (P <0.05). The ACT score in the observation group was significantly higher than that in the control group, and the exhaled NO level was significantly lower than that in the control group (P <0.05) The levels of IL-4, IL-25 and IL-33 in the observation group were significantly lower than those in the control group (P <0.05). The pulmonary function indexes such as FVC, FEV1 and FEV1 / FVC in the observation group were significantly higher than those in the control group 0.05). Conclusion: Huanglongshu soup combined with montelukast sodium treatment of bronchial asthma significant effect in patients with significant reduction of inflammatory cytokines, lung function can be effectively improved.