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目的:探讨一期后路全脊椎整块切除术治疗下腰椎（Ln 4、Ln 5）转移性肿瘤的可行性和临床效果。n 方法:回顾性分析自2012年1月至2018年6月23例行手术治疗的下腰椎转移性肿瘤患者资料，其中男14例，女9例；年龄（57.9±10.8）岁（范围37~74岁）。所有患者均行一期后路全脊椎整块切除、钛网植入、后路椎弓根钉棒系统内固定术治疗。统计的临床指标包括手术时间，术中失血量，术后住院时间，患者术前、术后1个月及术后6个月的疼痛视觉模拟评分（visual analogue scale，VAS）、美国东部肿瘤协作组（Eastern Cooperative Oncology Group，ECOG）体力状况评分，患者术前、术后的美国脊柱损伤协会（American spinal injury association，ASIA)脊髓损伤分级，围手术期并发症，局部复发情况及患者生存期。结果:本组23例中位随访时间为20个月（6~56个月），至末次随访仍有3例存活，其平均随访时间为（37.3±11.7）个月，其中1例出现局部复发，但仍带瘤生存。手术时间（258±96）min（范围155~510 min）；术中出血量（1258.7±528.6）ml（范围750~2 500 ml）；术后住院时间（18.4±4.6）d（范围10~30 d）。VAS评分由术前（7.4±0.8）分改善至术后1个月（2.6±0.6）分，ECOG评分由术前（1.6±0.9）分改善至术后6个月（0.9±0.7）分，与术前相比差异均具有统计学意义（n P<0.05）。6例出现术后急性神经根刺激症状，3例出现术后脑脊液漏，3例出现术后切口感染，1例肺部感染，3例随访期间出现钛网移位。n 结论:一期后路全脊椎整块切除术治疗下腰椎转移性肿瘤是可行的，虽然因为特殊的解剖结构和生物力学特性，该术式具有相当的挑战性，但远期随访效果满意。“,”Objective:To investigate the feasibility and clinical outcome of single-stage posterior total en bloc spondylectomy via posterior approach for lowerlumbar spinal malignant tumors.Methods:The clinical data of 23 patients with metastatic tumors of the lower lumbar spine who underwent single-stage posterior total En bloc spondylectomy in our hospital from January 2012 to June 2018 were analyzed retrospectively. There were 14 males and 9 females, age 57.9±10.8 years old (range, 37-74 years old). All patients were treated with single-stage posterior total en blocspondylectomy, titanium mesh implantation and posterior pedicle screw fixation. Observation items included operation time, intraoperative blood loss, postoperativehospital stays,the visual analogue scale (VAS) and the Eastern Cooperative Oncology Group (ECOG) physical condition score of the patients before operation,1 month after operationand 6 months after operation, the American spinal injury association (ASIA) spinal cord injury grade pre-operation andpostoperation, perioperative complications, local recurrence and survival state.Results:The median fellow-up time of this group was 20 months (range 6-56 months). At the end of the last follow-up, there were 3 patients who survived, the average follow-up time of the three patients who survived to the last follow-up was 37.3±11.7 months. One of them had local recurrence, but survived with tumor. The operative time was 155-510 min, with an average of 258±96 min, the intraoperative blood loss was 750-2 500 ml, with an average of 1 258.7±528.6 ml, and the postoperative hospital stay was 10-30 d, with an average of 18.4±4.6 d. VAS score decreased from 7.4±0.8 before operation to 2.6±0.6 1 month after operation, and ECOG score decreased from 1.6±0.9 before operation to 0.9±0.76 months after operation, showing statistically significant differences (n P<0.05). 6 patients presented with postoperative acute nerve root stimulation, 3 patients presented with postoperative cerebrospinal fluid leakage, 3 patients presented with postoperative surgical site infection, 1 with pulmonary infection, and 3 patients presented with titanium mesh displacement.n Conclusion:Single-stage posterior total En bloc spondylectomy is feasible for the treatment of metastatic tumors of the lower lumbar spine. Although the operation is quite challenging due to its special anatomical structure and biomechanical characteristics,the long-term follow-up effect is satisfactory.