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目的:探讨急性脑梗死并发代谢综合征患者血清高迁移率族蛋白B1(high mobility group box-1,HMGB1)水平与脑动脉狭窄的相关性。方法:将74例急性脑梗死患者分为代谢综合征组和非代谢综合征组,分别检测血清HMGB1、甘油三酯、总胆固醇、高密度脂蛋白及低密度脂蛋白,并通过核磁共振血管成像明确有无颅内外动脉粥样硬化狭窄,计算各组的发生率。结果:代谢综合征组血清HMGB1水平明显高于非代谢综合征组(P<0.05),代谢综合征组脑动脉狭窄发生率显著高于非代谢综合征组(P<0.05),但行单因素Logistic回归分析提示脑动脉狭窄与血清HMGB1水平无显著相关性(P>0.05),而与代谢综合征有关(P<0.05)。结论:代谢综合征可能与脑动脉的粥样硬化狭窄有关,HMGB1可能参与此病理过程中,但HMGB1与脑动脉狭窄无明显相关性。
Objective: To investigate the relationship between serum high mobility group box-1 (HMGB1) and cerebral artery stenosis in patients with acute cerebral infarction complicated with metabolic syndrome. Methods: Seventy-four patients with acute cerebral infarction were divided into metabolic syndrome group and non-metabolic syndrome group. Serum HMGB1, triglyceride, total cholesterol, high density lipoprotein and low density lipoprotein were detected by nuclear magnetic resonance angiography Clear whether intracranial and extracranial atherosclerosis stenosis, calculate the incidence of each group. Results: Serum levels of HMGB1 in the metabolic syndrome group were significantly higher than those in the non-metabolic syndrome group (P <0.05), and those in the metabolic syndrome group were significantly higher than those in the non-metabolic syndrome group (P <0.05) Logistic regression analysis showed that cerebral artery stenosis had no significant correlation with serum HMGB1 level (P> 0.05), but with metabolic syndrome (P <0.05). Conclusion: Metabolic syndrome may be related to atherosclerosis stenosis of cerebral arteries. HMGB1 may be involved in this pathological process, but there is no significant correlation between HMGB1 and cerebral artery stenosis.