Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment

• 作 者: Keitaro Hayashi Naohiko Anzai
• 机 构: DepartmentofPharmacologyandToxicology,DepartmentofPharmacology
• 出 处: World Journal of Gastrointestinal Oncology
• 发表日期: 2017年1期
• 关键词: LAT1 氨基酸 transporter 分子的目标药 氨基酸饥饿反应 信号 transduction LAT1 Amino acid transporter

L-type amino acid transporters(LATs) mainly assist the uptake of neutral amino acids into cells. Four LATs(LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1(SLC7A5) has been attracting much attention in the field of cancer research since it is