Genetic polymorphisms of interleukin 1β gene and sporadic pancreatic neuroendocrine tumors susceptib

• 作 者: Dimitrios Karakaxas Anna Sioziou Gerasimos Aravantinos Ahmet Coker Ioannis S Papanikolaou Theodoros Liakakos Christos Dervenis Maria Gazouli
• 机 构: Department of General Surgery,Agia Olga Hospital,Department of Basic Medical Sciences,Laboratory of
• 出 处: World Journal of Gastrointestinal Oncology
• 发表日期: 2016年06期
• 关键词: interleukin neuroendocrine allele intraductal mucinous neoplasm papillary adenoc

AIM.:To evaluate the association between the interleukin 1β(IL-1β) polymorphisms and the pancreatic neuroendocrine tumor(pN ET) development.METHODS.:A case-control study was conducted analyzing IL-1β polymorphisms using germline DNA collected in a population-based case-control study of pancreatic cancer(51 pN ET cases,85 pancreatic ductal adenocarcinoma cases,19 intraductal papillary mucinous neoplasm and 98 healthy controls).RESULTS.:The distribution of genotypes for the-511C/T polymorphism in the pN ET patient groups showed significant difference compared to the control group.It is known that the carriers of the IL-1β-511 T allele have increased concentrations of IL-1β.The-511 CT and TT high-expression genotypes were over-represented in pN ET patients.CONCLUSION.:The findings of this study suggested a possible role of IL-1β-511 C/T genotypes in the pathogenesis of pN ETs since the presence of the IL-1β-511 CT and TT genotypes and the T allele was associated with an increased risk of pN ET only.

AIM .: To evaluate the association between the interleukin 1β (IL-1β) polymorphisms and the pancreatic neuroendocrine tumor (pN ET) development. METHODS .: A case-control study was conducted analyzing IL-1β polymorphisms using germline DNA collected in a population -based case-control study of pancreatic cancer (51 pN ET cases, 85 pancreatic ductal adenocarcinoma cases, 19 intraductal papillary mucinous neoplasm and 98 healthy controls) .RESULTS.: The distribution of genotypes for the-511C / T polymorphism in the pN ET patient groups showed significant difference compared to the control group. It is known that the carriers of the IL-1β-511 T allele have increased increased concentrations of IL-1β.-511 CT and TT high-expression genotypes were over-represented in pN ET patients. CONCLUSION.: The findings of this study suggested a possible role of IL-1β-511 C / T genotypes in the pathogenesis of pN ETs since the presence of the IL-1β-511 CT and TT genotypes and the T allele was associated with an increased r isk of pN ET only.