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目的了解经过2008及2009年手足口病流行之后,福建省普通人群血清肠道病毒71型的抗体水平。方法采集2010年福建省390名普通人群的血清标本,采用中和试验检测血清EV71中和抗体。结果 390名普通人群中和抗体阳性186人,阳性率47.69%。男女性别之间中和抗体阳性率及抗体滴度均没有统计学差异(χ2=0.42,P=0.52>0.05;U=-0.24,P=0.81>0.05)。各个年龄组之间的抗体阳性率及抗体滴度均有统计学差异(χ2=55.69,P=0.00<0.05;HC=50.36,P=0.00<0.05),抗体阳性率最低的为0~岁年龄组,为16.67%,抗体阳性率随年龄增大而增高。0~4岁年龄组的抗体阳性率为25.33%,5~年龄组的抗体阳性率为61.67%,两者之间的抗体阳性率及抗体滴度均有统计学差异(χ2=48.85,P=0.00<0.05;U=-6.39,P=0.00<0.05)。结论经过2008及2009年手足口病流行之后,福建省普通人群血清肠道病毒71型的抗体水平仍较低,特别是0~4岁年龄组的儿童。今后福建省仍会出现EV71作为主要病原体之一引起的手足口病疫情,易感人群仍为5岁组以下儿童,应继续加强监测和防控。
Objective To understand the antibody level of serum enterovirus 71 in the general population of Fujian Province after the epidemic of HFMD in 2008 and 2009. Methods Serum samples from 390 common people in Fujian Province in 2010 were collected. Neutralization test was used to detect the serum neutralizing antibody of EV71. Results There were 186 positive neutralizing antibodies in 390 common people, the positive rate was 47.69%. There was no significant difference in the positive rate of neutralizing antibody and antibody titer between male and female (χ2 = 0.42, P = 0.52> 0.05; U = -0.24, P = 0.81> 0.05). The antibody positive rate and antibody titer between all age groups were statistically significant (χ2 = 55.69, P = 0.00 <0.05; HC = 50.36, P = 0.00 <0.05). The lowest antibody positive rate was 0 ~ Group, was 16.67%, antibody positive rate increased with age. The positive rate of antibody in 0-4 years old group was 25.33%, the positive rate of antibody in 5 ~ age group was 61.67%, the positive rate of antibody and antibody titer between the two groups were statistically significant (χ2 = 48.85, P = 0.00 <0.05; U = -6.39, P = 0.00 <0.05). Conclusion After the epidemic of HFMD in 2008 and 2009, the antibody level of serum enterovirus 71 in the general population in Fujian Province is still low, especially in children aged 0-4 years. In the future, there will still be epidemic HFMD caused by EV71 as one of the major pathogens in Fujian Province. Susceptible populations are still below 5-year-old children. Monitoring, prevention and control should continue to be strengthened.