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目的研究CXCR4、CCL21及CCR7在宫颈癌中的表达及其与临床病理参数的关系。方法采用免疫组化方法检测93例宫颈癌CXCR4、CCL21及CCR7蛋白表达水平。结果 CXCR4、CCR7、CCL21在宫颈癌组织中的阳性表达率分别72.0%(67/93)、68.8%(64/93)、75.3%(70/93),主要表达于细胞膜或/和细胞浆内。CXCR4、CCR7及CCL21阳性表达与宫颈癌细胞病理分化程度和临床分期有密切关系(P<0.05或P<0.01)。有淋巴结转移的CXCR4、CCR7及CCL21蛋白表达均显著高于无淋巴结转移组(P<0.01)。结论 CXCR4、CCR7及CCL21可能在促进宫颈癌淋巴结转移,它们的阳性表达在宫颈癌生长、侵袭和转移过程中起重要作用。
Objective To investigate the expression of CXCR4, CCL21 and CCR7 in cervical cancer and their relationship with clinicopathological parameters. Methods The expressions of CXCR4, CCL21 and CCR7 protein in 93 cases of cervical cancer were detected by immunohistochemistry. Results The positive rates of CXCR4, CCR7 and CCL21 in cervical cancer tissues were 72.0% (67/93), 68.8% (64/93) and 75.3% (70/93), respectively, which were mainly expressed in the cell membrane and / or cytoplasm . The positive expression of CXCR4, CCR7 and CCL21 was closely related to the pathological differentiation and clinical stage of cervical cancer (P <0.05 or P <0.01). The expressions of CXCR4, CCR7 and CCL21 protein in lymph node metastasis were significantly higher than those in non-lymph node metastasis group (P <0.01). Conclusion CXCR4, CCR7 and CCL21 may promote cervical lymph node metastasis, and their positive expression plays an important role in the growth, invasion and metastasis of cervical cancer.