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百日咳是由百日咳杆菌所引起,这是众所周知的。但早在1932年,Rich 在5例患百日咳而死亡者的肺,发现有细胞核内包涵体存在。他认为可能是疱疹病毒或未知病毒的二重感染。随后 Mc Cordock(1932)也证实了在35例百日咳死亡者中,有12例可以见到核内包涵体。Olson 等(1964)对4例临床诊断为百日咳和百日咳肺炎患者的鼻咽部,反复进行百日咳秆菌分离,结果均为阴性;但却分离出腺病毒12型。
Pertussis is caused by Bordetella pertussis, which is well known. But as early as 1932, Rich found nuclear inclusions in the lungs of five people who died of whooping cough. He thinks it may be a double infection of a herpes virus or an unknown virus. Subsequently Mc Cordock (1932) also confirmed that in 35 cases of death of whooping cough, 12 cases can see the nuclear inclusions. Olson et al. (1964) repeated the isolation of B. pertussis in 4 nasopharyngeal specimens of patients with pertussis and whooping cough who were clinically diagnosed, all of which were negative; however, adenovirus type 12 was isolated.