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目的探讨儿童首剂麻疹类疫苗在8~12月龄及>12月龄接种对其血清麻疹IgG抗体水平,评价麻疹类疫苗首剂接种月龄的选择。方法对2011年龙泉驿区人口麻疹血清流行病学调查项目中发现的首剂次麻疹类疫苗延迟接种(起始月龄>12月龄)对象9例,与在8~12月龄合格接种首剂麻疹类疫苗的对象,分别以最后1剂次麻疹类疫苗接种时间距监测时间间隔(年)、年龄、性别、接种剂次、常规接种2剂次时间间隔(年)等条件,按照1∶3进行配对,按《麻疹诊断标准》(WS296-2008)中规定的酶联免疫吸附试验(ELISA)间接法检测麻疹IgG抗体,应用EPI-INFO统计分析软件与IBM-SPSS20.0统计分析软件。结果麻疹类疫苗首剂接种起始月龄为8~12月龄与>12月龄,其麻疹抗体显性感染保护率(χ2=0.8,P=0.371 1,α=0.10)和抗体水平(t=0.669,t0.10,(8)=1.860,P>0.10,α=0.10)并无差别。结论将麻疹类疫苗首剂接种时间推迟至>12月龄并不能提高血清麻疹IgG抗体的阳性率、显性感染保护率和抗体水平,同时考虑到暴露风险,不支持将麻疹类疫苗的首剂接种时间推迟到1岁。
Objective To investigate the measles IgG antibody level of the first measles vaccine inoculated in children aged 8-12 months and> 12 months and to evaluate the choice of the first dose of measles vaccine for the first month of vaccination. Methods Nine cases of the first dose of measles vaccine (initial month> 12 months old) were found in the survey of measles epidemiology of population in Longquanyi district in 2011, Measles vaccine subjects, respectively, the last dose of measles vaccine from the monitoring time interval (year), age, sex, inoculation times, routine inoculation 2 doses time interval (years) and other conditions, according to 1: 3 The measles IgG antibody was detected by ELISA indirectly according to the diagnostic criteria of measles (WS296-2008). The software of EPI-INFO statistical analysis and the software of IBM-SPSS20.0 were used. Results The measles vaccine at the beginning of inoculation was 8-12 months old and> 12 months old. The measles antibody positive infection protection rate (χ2 = 0.8, P = 0.371 1, α = 0.10) and antibody level = 0.669, t 0.10, (8) = 1.860, P> 0.10, α = 0.10). Conclusions The delay of the first dose of measles vaccine to> 12 months of age did not improve the positive rate of measles IgG antibody, the rate of dominant infection protection and the antibody level, taking into account the risk of exposure and not supporting the first dose of measles vaccine Vaccination time postponed to 1 year old.