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Objective: Large cell carcinoma of lung is a very rare tumor.The clinical characteristics and CT imaging feature of large cell carcinoma of lung were discussed in this article.Methods: Eight cases of large cell carcinoma of lung proven by post-operational pathology were retrospectively analyzed from 2000 to 2005 and the literature on it was reviewed.Results: All 8cases were men.The average age of patients was 64.88 years.Seven cases were smokers.Six cases had obvious chest stuffy,short breath,thrill dry cough.Hereinto 3 cases had cardinal red blood sputum.CT images of large cell carcinoma of lung were represented as single and peripheral mass or nodule.The distribution of large cell carcinoma of lung was short of some rule.75% focus had clear finitude.One case showed internal calcification and 2 cases showed cavity.They did not show internal fat density.Conclusion: Large cell carcinoma of lung is difficult to be diagnosed before operation.Its CT finding is nonspecific.