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目的探讨脑栓塞患者在发病后不同时间段进行高压氧治疗的临床疗效。方法选择2014年6月至2015年6月入院,NIHSS评分超过5分,起病时间不超过48h的脑栓塞患者40例,通过随机分组的方式将其分为对照组和观察组,每组20例。其中观察组在患者起病48h内进行常规治疗,并同时进行HBO治疗;对照组先进行常规治疗,然后在起病15d之后再开始HBO治疗。5d为一个疗程,经过一个疗程治疗之后通过NIHSS评分评价疗效。经过三个月的治疗之后,使用改良Rankin评分评价疗效。结果两组患者在经过5d的治疗之后,NIHSS评分均无明显的差异,其中观察组有4例患者,对照组有2例患者,评分有所改善(P<0.05)。经过三个月的治疗之后,观察组有10例患者预后优良,对照组仅有2例预后良好,两组间的存活率差异不明显(P>0.05)。结论在脑栓塞患者急性期开展HBO治疗,治疗效果比单纯的常规治疗更好,并能有效的降低患者血浆当中的MDA的含量,越早使用效果越显著。
Objective To investigate the clinical efficacy of hyperbaric oxygen therapy in patients with cerebral embolism at different time points after onset. Methods Forty patients with cerebral embolism admitted from June 2014 to June 2015 with NIHSS score above 5 points and onset time less than 48 hours were divided into control group and observation group by randomization example. The observation group was treated routinely within 48 hours after the onset of the disease, and HBO treatment was performed at the same time. In the control group, routine treatment was performed first, and then HBO treatment was started 15 days after onset. 5d for a course of treatment, after a course of treatment by NIHSS score to evaluate the efficacy. After three months of treatment, the modified Rankin score was used to assess efficacy. Results There was no significant difference in NIHSS scores between the two groups after 5 days of treatment. There were 4 patients in the observation group and 2 patients in the control group, with an improvement in scores (P <0.05). After three months of treatment, 10 patients in the observation group had a good prognosis, while only 2 patients in the control group had a good prognosis. There was no significant difference in survival rate between the two groups (P> 0.05). Conclusions HBO treatment in patients with acute cerebral embolism is more effective than simple routine therapy and can effectively reduce the content of MDA in the plasma of patients. The earlier the effect of HBO is, the more effective the treatment is.