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目的:探讨移植肾动脉狭窄(TRAS)的早期诊断、治疗策略和预后,评价综合治疗TRAS的临床效果及安全性。方法:回顾性分析6例TRAS患者临床资料,总结其临床特点、诊断、疗效、并发症及转归等。结果:TRAS以顽固性高血压、肾功能异常、尿少和移植肾区血管杂音为主要临床特点;TRAS的早期诊断主要依据彩色多普勒血流显像(CDFI)和双源CT三维血管成像(DSCTA)。本组患者全部治疗成功,无一例出现严重并发症。随访期间,所有患者肾功能正常,血压稳定,生活质量良好。结论:早期诊断TRAS,并选择合理的综合治疗方案,对逆转TRAS导致的顽固性高血压和移植肾功能损害,提高移植人/肾的生存率有重要意义。
Objective: To investigate the early diagnosis, treatment strategy and prognosis of renal transplant artery stenosis (TRAS) and evaluate the clinical efficacy and safety of TRAS. Methods: The clinical data of 6 patients with TRAS were retrospectively analyzed. The clinical features, diagnosis, curative effect, complications and prognosis were summarized. Results: The clinical features of TRAS were refractory hypertension, renal dysfunction, oliguria, and renal vascular murmur. The early diagnosis of TRAS was mainly based on color Doppler flow imaging (CDFI) and dual-source CT angiography (DSCTA). All patients in this group were successfully treated, without any serious complications. During follow-up, all patients had normal renal function, stable blood pressure, and good quality of life. Conclusion: Early diagnosis of TRAS and the selection of a reasonable combination regimen are of great significance in reversing the intractable hypertension and impaired graft function induced by TRAS and improving the survival rate of human / renal graft.