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目的观察自拟五虫散结膏外敷配合抗结核药物治疗淋巴结结核的近期疗效。方法 176例淋巴结结核患者,随机分为治疗组(83例)与对照组(93例)。对照组常规应用HRZE方案(异烟肼、利福平、吡嗪酰胺、乙胺丁醇)抗结核治疗,治疗组在HRZE方案的基础上加用自拟五虫散结膏局部外敷治疗。观察两组临床治疗效果及不良反应发生情况。结果患者均按规定用药,治疗过程中无淋巴结破溃,且未进行手术治疗,无一例失访。治疗后第2、4、6、8周,治疗组治疗效果均明显优于对照组,差异具有统计学意义(U=5.094、5.897、6.611、6.766,P<0.05)。在临床治疗过程中,未发现患者发生明显皮肤过敏等不良反应,患者耐受性好。结论自拟五虫散结膏外敷配合抗结核药物治疗淋巴结结核,有提高近期疗效,且无明显不良反应,值得推广。
Objective To observe the short-term curative effect of self-formulated Wushen Sanjie Paste with topical antituberculosis drugs in treatment of lymph node tuberculosis. Methods A total of 176 patients with lymph node tuberculosis were randomly divided into treatment group (83 cases) and control group (93 cases). In the control group, HRZE regimen (isoniazid, rifampicin, pyrazinamide and ethambutol) were routinely used to treat tuberculosis. The treatment group was treated with local topical application of self-made Wushen Sanjiegao based on the HRZE regimen. The clinical effects and adverse reactions of the two groups were observed. Results Patients were prescribed medication, no lymph node rupture during treatment, and no surgical treatment, no case of lost. At 2, 4, 6, and 8 weeks after treatment, the therapeutic effect of the treatment group was significantly better than that of the control group (P = 0.05). The difference was statistically significant (U = 5.094,5.897,6.611,6.766, P <0.05). In the course of clinical treatment, patients found no obvious adverse reactions such as skin allergies, patients with good tolerance. Conclusion Wudong Sanjie Paste topical application of anti-tuberculosis drugs for treatment of lymph node tuberculosis, to improve the short-term efficacy, and no significant adverse reactions, it is worth promoting.