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目的:研究嗜酸性粒细胞趋化因子1(Eotaxin-1)在浆液性卵巢癌组织中的表达及临床病理意义。方法:收集2013年4月至2014年5月于我院妇产科手术切除的60例浆液性卵巢癌及对应癌旁组织,采用免疫组织化学染色检测Eotaxin-1表达,分析Eotaxin-1蛋白与肿瘤临床病理资料之间的相关性。结果:浆液性卵巢癌组织中Eotaxin-1蛋白表达水平较对应癌旁组织显著升高(P<0.05),浆液性卵巢癌组织中高表达Eotaxin-1蛋白与恶性组织病理分级、淋巴结转移及高TNM分期呈显著正相关(P<0.05)。结论:Eotaxin-1蛋白在浆液性卵巢癌组织中表达上调,并与肿瘤恶性临床病理特征有关;Eotaxin-1可能成为浆液性卵巢癌早期诊断的重要标志物和生物靶向治疗的有效靶点之一,具有广阔的临床应用前景。
Objective: To investigate the expression and clinicopathological significance of Eotaxin-1 in serous ovarian cancer. Methods: From April 2013 to May 2014, 60 cases of serous ovarian cancer and their corresponding paracancerous tissues resected in our hospital were collected. The expression of Eotaxin-1 was detected by immunohistochemical staining. The expression of Eotaxin-1 protein and Correlation between tumor clinicopathological data. Results: The expression of Eotaxin-1 protein in serous ovarian cancer tissues was significantly higher than that in corresponding adjacent tissues (P <0.05). The expression of Eotaxin-1 protein was significantly correlated with pathological grade, lymph node metastasis and high TNM in serous ovarian cancer Staging showed a significant positive correlation (P <0.05). CONCLUSION: Eotaxin-1 protein is up-regulated in serous ovarian cancer tissues and is related to clinicopathological features of malignant ovarian cancer. Eotaxin-1 may be an important biomarker for early diagnosis of serous ovarian cancer and a valid target of biological targeted therapy First, with broad prospects for clinical application.