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丙硫氧嘧啶和甲巯基咪唑常被用于治疗甲状腺机能亢进。有人曾描述,两名病人在用丙硫氧嘧啶治疗期间除孤立的粒细胞缺乏症外,免疫系统发生了不良影响。复习文献发现,35年间的53个类似病例。最常见的临床表现是皮疹、发热、关节痛和粒细胞减少。尤其是发生伴有皮肤症状的血管炎,并且可能是致死性的。临床证据表明,免疫机制受累。据报告有大量不同的自身抗体,但是抗核抗体却不常见,而且没有一例符合系统性红斑狼疮诊断标准。因此,这些反应不代表真正的药物引起的狼疮综合
Propylthiouracil and methylmercaptoimidazole are often used to treat hyperthyroidism. It has been described that in addition to isolated agranulocytosis, both patients had an adverse effect on the immune system during treatment with propylthiouracil. Review of the literature found that 53 similar cases in 35 years. The most common clinical manifestations are rash, fever, joint pain and neutropenia. In particular, vasculitis associated with cutaneous symptoms occurs and may be fatal. Clinical evidence shows that immune mechanisms are involved. A large number of different autoantibodies are reported, but antinuclear antibodies are uncommon and none of them meet the diagnostic criteria for systemic lupus erythematosus. Therefore, these responses do not represent a true drug-induced lupus syndrome