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目的观察新辅助放化疗、热疗联合腹腔镜手术治疗进展期直肠癌的临床效果。方法选择2010年1月-2012年6月住院治疗的86例进展期直肠癌患者为研究对象,应用随机数字表法将本研究入选患者分为对照组和观察组,每组43人,对照组患者进行新辅助放化疗联合腹腔镜手术治疗,而观察组患者则在术前新辅助放化疗和热疗后再行腹腔镜手术治疗,比较对照组和观察组患者临床疗效和放化疗反应发生情况,比较对照组和观察组患者局部复发的情况。结果观察组患者的治疗总有效率(70.09%)明显高于对照组患者(51.16%),差异有统计学意义(P<0.05),而观察组的放化疗反应并未较对照组患者明显增加(P>0.05)。结论新辅助放化疗、热疗联合腹腔镜手术治疗进展期直肠癌临床疗效确切,不良反应少,明显改善患者的预后,远期疗效有待进一步观察。
Objective To observe the clinical effect of neoadjuvant chemoradiation and hyperthermia combined with laparoscopic surgery for advanced rectal cancer. Methods A total of 86 patients with advanced colorectal cancer treated in our hospital from January 2010 to June 2012 were selected as the study subjects. The patients were divided into control group and observation group using random number table method, with 43 patients in each group and control group Patients underwent neoadjuvant chemoradiation combined with laparoscopic surgery while patients in the observation group received laparoscopic surgery before neoadjuvant chemoradiation and hyperthermia. The clinical efficacy and radiotherapy and chemotherapy response in the control group and observation group were compared , The control group and observation group patients with local recurrence. Results The total effective rate (70.09%) in observation group was significantly higher than that in control group (51.16%), the difference was statistically significant (P <0.05), but the radiotherapy and chemotherapy response in observation group was not significantly higher than that in control group (P> 0.05). Conclusions Neoadjuvant chemoradiation and hyperthermia combined with laparoscopic surgery for the treatment of advanced rectal cancer have definite clinical curative effect, few adverse reactions and significant improvement in the prognosis of patients. The long-term curative effect needs to be further observed.