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[目的]分析绝经前子宫内膜癌的危险因素,为临床诊治提供参考依据。[方法]2006年1月至2010年12月间因阴道出血就诊的绝经前患者1283例,其中子宫内膜正常1239例,子宫内膜癌44例;收集两组病例的临床资料,采用Logistic回归分析危险因素的危险度。[结果]多因素Logistic回归分析显示多囊卵巢综合征(PCOS)患者患子宫内膜癌风险是非PCOS的28.594倍(95%CI为11.983～73.407)。糖尿病者患有子宫内膜癌的风险是非糖尿病患者的43.965倍(95%CI为11.783～164.041)。三苯氧胺(TAM)使用史者患子宫内膜癌的风险是无TAM使用史的65.074倍(95%CI为8.993～476.172)。肿瘤家族史者患子宫内膜癌的风险是无肿瘤家族史患者的67.797倍(95%CI为9.622～377.687)。[结论]PCOS、糖尿病、TAM使用史和肿瘤家族史是子宫内膜癌的危险因素。针对危险因素采取防治措施对预防子宫内膜癌发病有着一定的价值。
[Objective] To analyze the risk factors of premenopausal endometrial cancer and provide reference for clinical diagnosis and treatment. [Methods] From January 2006 to December 2010, 1283 premenopausal patients with vaginal bleeding were treated, including 1239 cases of normal endometrium and 44 cases of endometrial cancer. The clinical data of two groups were collected and analyzed by Logistic regression Analysis of the risk of risk factors. [Results] Multivariate Logistic regression analysis showed that the risk of endometrial cancer in PCOS patients was 28.594 times higher than that of non-PCOS patients (95% CI: 11.983 ~ 73.407). Diabetic patients with endometrial cancer risk was 43.965 times non-diabetic patients (95% CI 11.783 ~ 164.041). The risk of history of endometrial cancer with tamoxifen (TAM) was 65.074-fold (95% CI, 8.993 to 476.172) for patients without TAM. Family history of cancer patients with endometrial cancer risk was 67.797 times the family history of tumor-free (95% CI 9.622 ~ 377.687). [Conclusion] PCOS, diabetes mellitus, TAM use history and tumor family history are the risk factors of endometrial cancer. To take prevention and treatment measures for risk factors to prevent the incidence of endometrial cancer has a certain value.