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目的为了解绝经前妇女手术云热后雌激素变化及骨密度的改变。方法随机选择20例绝经前期因妇科良性疾患接受全子宫加双附件切除者,分别于术前及术后各期作雌二醇测定,随访围绝经期综合征症状出现与否,其中6例于1a后作了骨密度测定。结果经统计学处理显示手术去势者术后雌激素水平急骤显著下降,围绝经期综合征的出现落后于雌激素低谷之后,被随访患者的骨密度比正常同年龄组下降6%。结论为防止骨质疏松症的发生,该类患者应尽早进行激素替代疗法。
Objective To understand the changes of estrogen and bone mineral density in premenopausal women after operation. Methods 20 premenopausal women with benign gynecological diseases who underwent total hysterectomy and double attachment excision were enrolled in this study. Estradiol was measured preoperatively and postoperatively respectively. The incidence of perimenopausal symptoms was followed up, 6 Bone mineral density was measured after 1a. Results The statistical analysis showed that the postoperative estrogen level of the castrated patients dropped dramatically and the incidence of perimenopausal syndrome lagged behind that of estrogen. The bone mineral density of follow-up patients decreased by 6% compared with the same age group. Conclusion To prevent the occurrence of osteoporosis, such patients should be hormone replacement therapy as soon as possible.