论文部分内容阅读
乙肝疫苗阻断乙肝病毒母要传播的作用已为国内外研究所充分肯定,但仍有10—20％的高危产儿不能得到疫苗的有效保护即免疫失败[1]。如何逆转免疫失败为国内外研究所关注。有一些学者主张进行加强接种,但加强接种的效果仍有争议,且大多数研究侧重于成人免疫失败者的研究,对免疫失败婴儿的研究较少_2。]。 我们从1987年10月-1994年12月间到我院乙肝疫苗门诊随访的婴儿中选择了55例初次乙肝疫苗全程免疫失败的耍儿进行加强接种.观察了加强接种的效果,并对影响加强接种效果的因素进行探讨。 对象和方法 一、对象 1987年10月至1994年12月在上海医科大学附属中山医院妇产科和上海市国际妇要保健院产科出生,母亲为HBsAg阳性的婴儿.生后按O、
The role of hepatitis B vaccine in blocking mother-to-child transmission of hepatitis B virus has been fully confirmed by the research institutes both at home and abroad. However, 10-20% of high-risk babies are still unable to obtain the effective protection of vaccines, ie, immune failure [1]. How to reverse the immune failure has attracted the attention of domestic and foreign research institutes. Some scholars advocate intensified vaccination, but the effect of vaccination is still controversial, and most of the studies focused on the study of adult immunocompromised persons, and less on immunocompromised infants2. ]. We selected 55 infants who failed the first full-course immunization of hepatitis B vaccine from infants who were followed up from hepatitis B vaccine clinics in our hospital from October 1987 to December 1994. We observed the effect of intensified vaccination and strengthened its influence Inoculation effect of the factors to be explored. Subjects and methods First, the object October 1987 to December 1994 in Zhongshan Hospital Affiliated to Shanghai Medical University Obstetrics and Gynecology and Shanghai International Women’s Hospital obstetrics and Gynecology, the mother of HBsAg-positive infants after birth by O,