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目的 :研究血管紧张素 (1 7) [Ang (1 7) ]对正常豚鼠心室肌细胞L 型钙离子通道的影响 ,旨在探讨Ang (1 7)发挥降压作用的离子通道及分子基础。 方法 :应用膜片钳全细胞记录技术。结果 :Ang (1 7)可使ICa L呈浓度依赖性增加 ,选择性AngⅠ型 (AT1)受体拮抗剂缬沙坦或非选择性AT1受体拮抗剂Sarthran(Sar)均可消除Ang (1 7)增加ICa L的作用。结论 :Ang (1 7)通过AT1受体增加ICa L,其降压作用不是通过抑制钙离子内流而实现的。
Objective: To investigate the effect of angiotensin (1 7) [Ang (17)] on L-type calcium channel in normal guinea pig ventricular myocytes in order to explore the ion channel and molecular basis of Ang (17) exerting antihypertensive effect. Methods: Patch clamp whole cell recording technique was used. Results: Ang (1 7) increased ICa L in a concentration-dependent manner. Valsartan, a selective angiotensin II type 1 receptor antagonist, or Sarthran (Sar), a nonselective AT1 receptor antagonist, 7) increase the role of ICa L. CONCLUSIONS: Ang (17) increases ICa L via AT1 receptors, and its antihypertensive effects are not mediated by inhibition of calcium influx.