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前言为了估计肺功能,用力呼气肺量图(Forced expiratory spirogram)已被广泛地应用。但是从用力呼气曲线得出的许多参数,除了FEV_1/FVC(第一秒时间肺活量百分值)外,均和受试者的年龄、性别、肺体积有关:因此,许多学者试图从用力呼气肺量图中求得与肺容量变化无关的时间因素。1974年Fish等首先把平均排出时间(Mean Transit Time,MTT)应用于临床,他改变了既往在血管内注入指示剂,测定用力呼气时气体分子自肺泡到大气MTT方法,而直接从用力
Introduction Forced expiratory spirogram has been widely used to estimate lung function. However, many parameters derived from forced expiratory curves, except for the FEV 1 / FVC (first-second spirometry percentage), are related to the subject’s age, sex, and lung volume: therefore, The time factor that is independent of lung volume change is obtained in the air volume map. In 1974, Fish et al. First used Mean Transit Time (MTT) in clinical practice. He changed the previous intravascular injection of indicator to determine the gas molecules from alveolar to atmospheric MTT during exhalation,