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目的评价LC-MS/MS法他克莫司试剂盒检测他克莫司血药浓度的可靠性。方法对近2年室内质控结果进行回顾性分析,并对各组数据进行统计学分析,从检测结果的回收率、合格率、标曲的相关性等指标进行评价。结果低、中、高浓度的质控样品的RSD分别为7.68%、7.35%、6.70%,合格率分别为98.10%、96.47%、97.10%。结论此检测方法操作简便、测定结果准确可靠,适用于临床上对他克莫司血药浓度的测定。
Objective To evaluate the reliability of tacrolimus LC-MS / MS assay for tacrolimus plasma concentration. Methods Retrospective analysis was made on the results of laboratory quality control in the past two years. The data of each group were statistically analyzed, and the results were obtained from the indexes such as the recovery rate of the test results, the pass rate and the correlation of the standard curve. Results The RSD of low, middle and high quality control samples were 7.68%, 7.35% and 6.70%, respectively. The pass rates were 98.10%, 96.47% and 97.10% respectively. Conclusion This method is simple, accurate and reliable, suitable for the clinical determination of tacrolimus plasma concentration.