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石蒜科文殊兰属植物文殊兰(Crinum asiaticum)、西南文殊兰(C.latifolium)、毛里求斯文殊兰(C.augustum)和C.pratens,从中分离出一个石蒜科生物碱Hippadine,化学名为4,5—乙烯基—8,9—亚甲二氧基—6—菲啶酮(Ⅰ)。发现它对鼠睾丸功能产生影响,并期望能找到一个可能的抗生育剂。对鼠腹腔内给予200mg/kg的Ⅰ,无死亡。每100g体重的鼠,每天用1.5mg Ⅰ处理其附睾溢出液一次,共三天,四天后处死发现精子有相当数量的减少,其DNA含量也
The genus Helminthia (Crinum asiaticum), C. latifolium, C. augustum, and C. pratens from the genus Amaryllidaceae, from which an alkaloid, Hippadine, was isolated. 4,5-vinyl-8,9-methylenedioxy-6-phenanthridone (I). It was found to have an effect on the testicular function of rats and it is expected to find a possible anti-fertility agent. Mice were intraperitoneally administered with 200 mg/kg of I without death. For each 100g body weight of rats, their epididymal fluid was treated once daily with 1.5mg I for a total of three days. After four days of sacrifice, a significant reduction in spermatozoa was found and DNA content was also