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目的观察三维适形放疗联合NP方案同步放化疗治疗Ⅲ期非小细胞肺癌的疗效及毒副反应。方法2005年1月至2010年10月收治50例Ⅲ期非小细胞肺癌患者于三维适形放疗同步联合NP方案治疗(适形组),放疗采用常规分割方法,6mVX总剂量60～66Gy;伴锁骨上淋巴结转移给予6MVX射线及6～15MeV的电子线,总剂量6～70Gy。另收集同时期常规放疗同步联合NP方案治疗(常规组)作对照,DT60～66Gy。两组均于第1周给予NP方案化疗,从第2周开始实施放疗,化疗21d为1个周期,连续2个周期。结果适形组和常规组总有效率分别为86%、64.6%(P=0.014)。适形组优于常规组。结论三维适形放疗同步NP方案与常规放疗同步联合NP方案治疗Ⅲ期非小细胞肺癌相比能够提高治疗的有效率,两组1、2a生存率相似,适形组明显降低了放疗相关副反应的发生率。
Objective To observe the efficacy and side effects of three-dimensional conformal radiotherapy combined with NP regimen in concurrent chemotherapy and radiotherapy for stage Ⅲ non-small cell lung cancer. Methods From January 2005 to October 2010, 50 patients with stage Ⅲ non-small cell lung cancer underwent three-dimensional conformal radiotherapy combined with NP regimen (conformal group). The conventional radiotherapy method was used. The total dose of 6mVX was 60-66 Gy Supraclavicular lymph node metastasis given 6MVX rays and 6 ~ 15MeV electronic lines, the total dose of 6 ~ 70Gy. Another collection of the same period conventional radiotherapy combined with NP regimen (conventional group) as a control, DT60 ~ 66Gy. Both groups were given NP chemotherapy in the first week, and started radiotherapy in the second week. The chemotherapy was given for one cycle 21 days after chemotherapy for two consecutive cycles. Results The total effective rate in conformal group and conventional group was 86% and 64.6%, respectively (P = 0.014). The conformal group is superior to the conventional group. Conclusions The three-dimensional conformal radiotherapy synchronized NP regimen can improve the treatment efficiency compared with the conventional radiotherapy and NP regimen in the treatment of stage Ⅲ non-small cell lung cancer. The survival rates of the two groups are similar at 1 and 2 years, and the conformal group significantly reduces the radiotherapy-related side effects The incidence of.