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为研究航天特殊环境对机体神经内分泌免疫功能的影响，探讨了超重与模拟失重对小鼠脑递质去甲肾上腺素（ＮＡ）、多巴胺（ＤＡ）、五羟色胺（５～ＨＴ）、血浆皮质酮及淋巴细胞转化的影响。结果表明，３级起飞曲线峰值５Ｇ加速度（约８００Ｇｓ）作用后即刻ＮＡ、ＤＡ升高，皮质酮和Ｔ细胞转化增加，Ｂ细胞转化显著降低，作用后７２小时ＮＡ、ＤＡ、皮质酮恢复，Ｔ、Ｂ细胞转化明显升高，５－ＨＴ升高，作用后１４４小时ＮＡ、ＤＡ、５－ＨＴ均恢复正常组水平，皮质酮则明显降低，Ｔ、Ｂ细胞转化开始恢复，但仍高于正常对照组水平。模拟失重等因素作用１２ｄ，小鼠脑ＮＡ、ＤＡ升高，５－ＨＴ无变化，皮质酮明显升高，Ｔ、Ｂ细胞转化明显降低。
In order to study the effect of aerospace special environment on neuroendocrine immune function, the effects of overweight and simulated weightlessness on neurotransmitter norepinephrine (NA), dopamine (DA), serotonin (5 ~ HT), plasma corticosterone Effect of lymphocyte transformation. The results showed that NA and DA were increased immediately after 3G takeoff curve peaked at 5G acceleration (about 800Gs), corticosterone and T cell transformation increased, B cell transformation decreased significantly, 72h after NA, DA, corticosterone recovery, T , B cell transformation was significantly increased, 5-HT increased after 144 hours NA, DA, 5-HT were restored to normal levels, corticosterone was significantly reduced, T, B cell transformation began to recover, but still higher than normal Control group level. Simulated weightlessness and other factors 12d, mouse brain NA, DA increased, 5-HT was unchanged, corticosterone was significantly increased, T, B cell transformation was significantly reduced.