艾蒿中黄酮的抗肿瘤活性

• 作 者: 王洋
• 出 处: 国外医学(中医中药分册)
• 发表日期: 2005年01期
• 关键词: 艾蒿 黄酮 抗肿瘤活性 绒毛尿囊膜 小鼠体重 活性试验 大鼠 甲氧基 生物活性 洗脱

采用生物活性指导分离,从菊科植物艾蒿(Artemisiaargyi)的地上部分得到6个黄酮(1～6),并对其抗肿瘤活性进行了研究。干燥的艾蒿地上部分(2kg)经甲醇(4L×2)室温提取24h。提取液合并浓缩,黑色残余物(85g)经硅胶急骤层析分离,用氯仿-甲醇梯度洗脱(99∶1→90∶10)。用法尼基蛋白转

Using biological activity to guide the isolation, six flavonoids (1 to 6) were obtained from the aerial part of Artemisia argyi, and the antitumor activity was studied. The aerial part of dried Artemisia halodendron (2 kg) was extracted with methanol (4L×2) for 24 h at room temperature. The extracts were combined and concentrated and the black residue (85 g) was flash chromatographed on silica gel eluting with a chloroform-methanol gradient (99:1→90:10). Usage protein