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目的:探讨埃索美拉唑治疗老年胃溃疡的幽门螺杆菌(HP)根除效果及对基质金属蛋白酶(MMP)、金属蛋白酶组织抑制剂-1(TIMP-1)表达的影响。方法:选取2014年6月至2015年6月于我院进行治疗的180例老年胃溃疡患者,随机分为对照组和观察组,各90例。对照组给予奥美拉唑治疗,观察组给予埃索美拉唑治疗。比较两组患者的临床疗效、Hp根除率及不良反应发生率,治疗前后MMP-3、MMP-7、MMP-9和TIMP-1的表达情况。结果:观察组患者的临床治疗总有效率(93.3%)明显高于对照组(72.2%)(P<0.05);观察组患者的HP根除率(87.8%)明显高于对照组(66.7%),差异有统计学意义(P<0.01);观察组患者的不良反应发生率(3.3%)明显低于对照组(14.4%)(P<0.05);治疗后,两组患者的MMP-3、MMP-7、MMP-9和TIMP-1的表达均降低(P<0.05),且观察组较对照组更显著(P<0.05)。结论:埃索美拉唑治疗老年胃溃疡能够显著根除HP,临床疗效显著且安全可靠,此外,还能够有效降低MMP-3、MMP-7、MMP-9和TIMP-1的表达。
Objective: To investigate the effect of esomeprazole on the eradication of Helicobacter pylori (HP) and the expression of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in elderly patients with gastric ulcer. Methods: A total of 180 elderly patients with gastric ulcer who were treated in our hospital from June 2014 to June 2015 were randomly divided into control group and observation group, 90 cases each. The control group was given omeprazole and the observation group was treated with esomeprazole. The clinical efficacy, Hp eradication rate and the incidence of adverse reactions were compared between the two groups. The expression of MMP-3, MMP-7, MMP-9 and TIMP-1 were detected before and after treatment. Results: The total clinical effective rate (93.3%) in the observation group was significantly higher than that in the control group (72.2%) (P <0.05). The HP eradication rate in the observation group (87.8%) was significantly higher than that in the control group (66.7% , The difference was statistically significant (P <0.01). The incidence of adverse reactions in the observation group (3.3%) was significantly lower than that in the control group (14.4%) (P <0.05) The expression of MMP-7, MMP-9 and TIMP-1 were decreased (P <0.05), and the observation group was more significant than the control group (P <0.05). Conclusion: Esomeprazole can eradicate HP significantly in elderly patients with gastric ulcer. The clinical efficacy is significant and safe. In addition, it can effectively reduce the expression of MMP-3, MMP-7, MMP-9 and TIMP-1.