论文部分内容阅读
热休克蛋白(HSPs)是广泛存在于生物体内的高度保守的一类应激蛋白。HSP对各种刺激具有迅速的反应能力,发挥抗炎、抗氧化、抗细胞凋亡以及分子伴侣等作用,在细胞的生长发育、代谢分化、基因转录、维持组织细胞的自稳和环境适应性方面扮演着重要角色。而其中最受研究者关注的是HSP70,其在生理状态下少量表达,可通过热预处理、药物以及基因转染等方法诱导其产生,从而发挥细胞保护作用。本文就HSP70在急性胰腺炎中的作用以及相关机理的研究进展做一综述。
Heat shock proteins (HSPs) are a highly conserved class of stress proteins found widely in the body. HSP has a rapid response to various stimuli, play an anti-inflammatory, anti-oxidation, anti-apoptosis and molecular chaperone and other roles in cell growth and development, metabolic differentiation, gene transcription, maintaining cell self-sustainability and environmental adaptability Aspects play an important role. Among them, most researchers are concerned with HSP70, which is expressed in a small amount under physiological conditions and can exert its cytoprotective effects by inducing its production through heat pretreatment, drugs and gene transfection. This article reviews the role of HSP70 in acute pancreatitis and its related mechanisms.