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目的:研究合成骨混合剂(含木黄酮结合其他预防骨质疏松的膳食营养)对绝经后妇女骨密度(BMD)的影响。方法:在6个月的双盲试验研究中,将70名受试者随机分为只接受钙剂的对照组和接受骨混合剂(GBB)的试验组,骨混合剂由异黄酮(30 mg.d-1)、维生素D3(800 IU.d-1)、维生素K1(150μg.d-1)组成。评估了骨吸收和形成的标志以及股骨颈、Ward三角区、转子和转子间的BMD。结果:补充GBB的受试者(n=30)股骨颈的BMD基本不变,而在对照组中(n=28),BMD显著下降(P=0.007)。在Ward三角区的两组之间也存在显著差异性(P<0.05),GBB组显著高于对照组。同时与基线和对照组相比,骨特异性碱性磷酸酶和N-端肽在GBB组中显著下降。结论:GBB有助于预防骨质疏松症并降低骨折风险,至少能够降低绝经后妇女臀部骨质疏松症和骨折的风险。
OBJECTIVE: To study the effect of synthetic bone mix (including dietary nutrition containing genistein and other osteoporosis) on bone mineral density (BMD) in postmenopausal women. METHODS: In a 6-month, double-blind trial, 70 subjects were randomized to receive either a calcium-only control group and a test group that received a bone mix (GBB) consisting of isoflavones (30 mg .d-1), vitamin D3 (800 IU.d-1) and vitamin K1 (150 μg.d-1). The signs of bone resorption and formation as well as the femoral neck, Ward trigone, BMD between the rotor and the rotor were evaluated. RESULTS: Subjects in the GBB (n = 30) BMD of the femoral neck remained essentially unchanged, whereas BMD decreased significantly in the control group (n = 28) (p = 0.007). There were also significant differences between the two groups in the Ward Triangle Zone (P <0.05), significantly higher in the GBB group than in the control group. At the same time, bone-specific alkaline phosphatase and N-telopeptide were significantly decreased in the GBB group compared to baseline and control group. CONCLUSION: GBB helps prevent osteoporosis and reduce the risk of fracture, at least reducing the risk of hip osteoporosis and fractures in postmenopausal women.