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In order to improve the bioavailability, Radix salvia miltiorrhiza raw powder mixed with distilled water (5.5wt%) was ultrafinely ground to nanosize particles using HSCS pulverizer, and the dissolving-out quantity of tanshinone IIA in the filtrate that obtained from nanoparticles suspension and raw powder marinated in water for different time was determined by HPLC. The experimental results show that raw powder can be ultrafinely ground to 133.5 nm at 1500 r/min for 50 min and the molecular structure of active ingredients doesnot change, and the dissolving-out quantity of tanshinone IIA obtained from the filtrate is increased greatly from 12.77 μg/g to 54.55 μg/g.
In order to improve the bioavailability, Radix salvia miltiorrhiza raw powder mixed with distilled water (5.5wt%) was ultrafinely ground to nanosize particles using HSCS pulverizer, and the dissolving-out quantity of tanshinone IIA in the filtrate that obtained from nanosuspension and raw The powder marinated in water for different time was determined by HPLC. The experimental results show that raw powder can be ultrafinely ground to 133.5 nm at 1500 r/min for 50 min and the molecular structure of active ingredients does not change, and the dissolving-out quantity Of tanshinone IIA obtained from the filtrate is driven from 12.77 μg/g to 54.55 μg/g.